Serving as a contract research organization (CRO), Endotherm Life Science Molecules is a provider of medicinally relevant compounds for the discovery and development of novel small molecule drugs. The product range includes focused and diversified compound libraries, reference standards, building blocks and fluorescent probes for assay development.
In cooperation CompChem Solutions, a molecular modelling provider, rational drug design efforts are supported by computer assisted tools towards the design of focused compound libraries for hit-finding, hit-to-lead studies and lead optimizations.
Besides the support for projects in medicinal chemistry and exclusive synthesis of rare compounds for dedicated customers, approximately 2500 “inhouse-made” research chemicals can be selected from a continuously updated catalogue.
Particularly, the company has established a technology platform for the synthesis of complex chiral natural products, such as Vitamin D derivatives, in turn to be used as compound libraries for screening, building blocks or for process research.
Finally, Endotherm Life Science Molecules is involved with internal drug discovery programmes, such as EUTrigTreat, an EU funded integrated FP7 research project. The consortium has the aim to explore the genetic and environmental cause of arrhythmias and sudden cardiac death in order to develop new diagnostic tools and effective therapies. In collaboration with the Universit?t Heidelberg, new inhibitors of Mur-A, a target enzyme for the development of new antibiotics, are discovered.
Germany
